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Saturday, October 16, 2021

The effect of “salt” in preventing the growth of tumors

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Researchers have recently found in a study of mice that a high-salt diet can fight the growth of tumors.

According to News i and quoted by TN, Although high-salt diets generally have negative effects on people’s health, raising blood pressure and affecting the cardiovascular system, new research published in the journal Science Advances suggests that high salt intake may have a negative effect. Have a wait.

The study was conducted by a team of researchers at the NCR-Biotech Science Cluster in the northern Indian state of Haryana. High salt intake has previously been linked to an exacerbation of inflammation, and a 2013 study in mice found that high levels of salt in mice could trigger symptoms of experimental autoimmune encephalomyelitis (EAE).

But inflammation is a protective response by the body, and the researchers in this study, led by Professor Amit Awasthi, wanted to see if a high-salt diet could also stimulate inflammation against the body’s anti-cancer response.

In this study, researchers fed tumor mice on a low-, medium-, and high-salt diet. Tumor size and cellular and metabolic composition were then carefully controlled. A high-salt diet significantly limited the growth of rat tumors. The researchers observed increased survival and decreased tumor growth in mice with melanoma, carcinoma and even metastatic cancer.

“Our analysis showed that the number of immune cells called natural killer cells increased by 50 percent in mice fed a high-salt diet,” Avasti said. These cells act as an internal tool of the immune system, identifying and destroying cells in the body that have become viral or cancerous. Tumor microenvironment is a strong suppressor of the immune system. Tumor microenvironment is the environment around the tumor, which includes the surrounding blood vessels, immune cells, fibroblasts, signaling molecules, and extracellular matrix (ECM).

Tumors have different biochemical defense walls, which allows them to resist the attack of natural killer cells and other inflammatory processes. Therapies such as immunosuppression inhibitors that ignore these defenses have been a very revolutionary treatment in cancer research.

Checkpoint inhibitor is a type of cancer immunotherapy that targets immune testing that regulates and controls the immune system. Some cancer cells can stimulate this process to protect themselves from an immune system attack. Immunosuppressive therapies are able to normalize immune function by blocking inhibitory immunosuppression.

“Everybody is talking about cancer immunotherapy these days,” Avasti added. The drugs used in these cases are approved by the US Food and Drug Administration and are very effective, but no one knows why these treatments only work on some patients. For example, these drugs only work in 30 to 40% of patients and not for other patients. .

The difference in the body’s response to drugs was another issue that the researchers looked at and found that the microbiome was one of the most effective treatments. Microbiomes are a collection of microbes that live in our bodies, and the metabolism of drugs by these bacteria (which vary from person to person) can greatly affect their performance.

To examine the microbiome of cancer mice, the researchers performed a detailed metabolic and RNA analysis of blood and fecal samples taken from the mice. The researchers found that one species of gut bacterium called bifidobacterium was very high in mice that followed a high-salt diet. They found that high salt intake significantly increased the permeability of the rat intestine, which meant that enriched Bifidobacterium could migrate from the intestine to other areas of the body, including the areas where the tumors were located.

The researchers found that when these bacteria were exposed to the tumor microenvironment, they suppressed the suppressed cells of the natural killer cell, enabling them to improve their antitumor attack.

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